For research use only. Not for therapeutic Use.
(S)-(-)-5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist.
| Catalog Number | I001235 |
| CAS Number | 1321546-70-6 |
| Synonyms | (2S)-2-amino-3-(5-fluoro-2,4-dioxopyrimidin-1-yl)propanoic acid;hydrochloride |
| Molecular Formula | C7H9ClFN3O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C7H8FN3O4.ClH/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12;/h1,4H,2,9H2,(H,13,14)(H,10,12,15);1H/t4-;/m0./s1 |
| InChIKey | TXWOAFHJFQTAEW-WCCKRBBISA-N |
| SMILES | C1=C(C(=O)NC(=O)N1CC(C(=O)O)N)F.Cl |
| Reference | [1]. Hawkinson JE, et al. Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding. Eur J Pharmacol. 1997 Jun 25;329(2-3):213-21. [2]. Kessler M, et al. Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators. Brain Res. 2006 Mar 3;1076(1):25-41. [3]. Rembach A, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004 Aug 15;77(4):573-82. |
