For research use only. Not for therapeutic Use.
Potent and selective dopamine (DA) D2-receptor agonist; more active (S)- enantiomer of 5-OH-DPAT (Axon 1006); its opposite enantiomer, R-5-OH-DPAT (Axon 1007), is a weakly potent D2 antagonist
| Catalog Number | I047446 |
| CAS Number | 182210-74-8 |
| Molecular Formula | C16H25NO.HBr |
| Purity | ≥95% |
| IUPAC Name | 6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol;hydrobromide |
| InChI | InChI=1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-8-9-15-13(12-14)6-5-7-16(15)18;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H |
| SMILES | CCCN(CCC)C1CCC2=C(C1)C=CC=C2O.Br |
| Reference | A. Karlsson et al. (R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): Assessment of optical purities and dopaminergic activities. Chirality. 1989-1995, 2(2), 90-95.
B Shi et al. Radiosynthesis and in vitro evaluation of 2-(N-alkyl-N-1′-11C-propyl)amino-5-hydroxytetralin analogs as high affinity agonists for dopamine D-2 receptors.Nucl Med Biol. 1999, 26(7), 725-35. (PubMed)
J Mukherjee et al. In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist (11)C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate.Synapse. 2000, 37(1), 64-70. (PubMed) |
