For research use only. Not for therapeutic Use.
Potent, selective and orally active prostaglandin D2 (PGD2) receptor DP antagonist, Ki values to be 1.6 and 24.2 nM for human DP and TP receptors
| CAS Number | 209268-36-0 |
| Molecular Formula | C25H31NO4S |
| Purity | ≥95% |
| IUPAC Name | (Z)-7-[(1R,2R,3S,5S)-2-[(5-hydroxy-1-benzothiophene-3-carbonyl)amino]-6,6-dimethyl-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acid |
| InChI | InChI=1S/C25H31NO4S/c1-25(2)16-11-15(7-5-3-4-6-8-22(28)29)23(20(25)12-16)26-24(30)19-14-31-21-10-9-17(27)13-18(19)21/h3,5,9-10,13-16,20,23,27H,4,6-8,11-12H2,1-2H3,(H,26,30)(H,28,29)/b5-3-/t15-,16-,20-,23+/m0/s1 |
| SMILES | CC1([C@H]2C[C@@H]([C@H]([C@@H]1C2)NC(=O)C3=CSC4=C3C=C(C=C4)O)C/C=C\CCCC(=O)O)C |
| Reference | A Arimura et al. Prevention of Allergic Inflammation by a Novel Prostaglandin Receptor Antagonist, S-5751. J. Pharmacol. Exp. Ther. 2001, 298(2), 411-419.
S Mitsumori et al. Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists… J. Med. Chem. 2003, 46(12), 2446-55. |
