For research use only. Not for therapeutic Use.
5-HT1A receptor partial agonist, less active enantiomer of (±)-8-OH-DPAT (Axon 1015), in comparison with R-(+)-8-hydroxy-DPAT (Axon 1016) as a full 5-HT1A agonist
| Catalog Number | I035906 |
| CAS Number | 78095-20-2 |
| Molecular Formula | C16H25NO.HBr |
| Purity | ≥95% |
| IUPAC Name | (7S)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol;hydrobromide |
| InChI | InChI=1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m0./s1 |
| SMILES | CCCN(CCC)[C@H]1CCC2=C(C1)C(=CC=C2)O.Br |
| Reference | T Yoshitake and J Kehr. Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 2004, 74, 2865.
LJ Cornfield et al. Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. Mol. Pharmacol. 1991, 39, 780. |
