For research use only. Not for therapeutic Use.
S-8510, also known as SB-737552, is a GABA-A receptor inverse agonist potentially for the treatment of dementia. S-8510 ameliorated memory impairment induced by cholinergic deficit in the water maze paradigm of Wistar rats. S-8510 augmented LTP of the Schaffer collateral/commissural fiber-CA1 synapses in the hippocampal slice preparations of SD rat. S-8510 increased the extracellular levels of acetylcholine and noradrenaline in the hippocampus of Wistar rat. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice.
| Catalog Number | I009267 |
| CAS Number | 151224-83-8 (free base) |
| Synonyms | S-8510; SB-737552; S8510; SB737552; S 8510; SB 737552.;2-(isoxazol-3-yl)-1,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine |
| Molecular Formula | C12H10N4O2 |
| Purity | ≥95% |
| Target | GABA-A receptor inverse agonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| SMILES | C12=NC=C3C(NC(C4=NOC=C4)=N3)=C1COCC2 |
| Reference | </br> 1:Chorvat RJ, Zaczek R, Brown BS. Ion channel modulators that enhance acetylcholine release: potential therapies for Alzheimer/’s disease. Expert Opin Investig Drugs. 1998 Apr;7(4):499-518. PubMed PMID: 15991988.</br> 2:Kominami G, Nakamura M, Chomei N, Takada S. Radioimmunoassay for a novel benzodiazepine inverse agonist, S-8510, in human plasma and urine. J Pharm Biomed Anal. 1999 Jun;20(1-2):145-53. PubMed PMID: 10704018.</br> 3: Tanaka H, Mizojiri K. Drug-protein binding and blood-brain barrier permeability. J Pharmacol Exp Ther. 1999 Mar;288(3):912-8. PubMed PMID: 10027826. |
