For research use only. Not for therapeutic Use.
S-8510（Cat No.:I009267）is a synthetic compound used primarily in scientific research, known for its potential applications in medicinal chemistry and pharmacology. As a free base, it is the non-salt form of the substance, typically used for studying the compound’s intrinsic properties, such as solubility, stability, and biological activity. Research often explores S-8510’s interactions with various receptors and enzymes, investigating its potential therapeutic uses or toxicity profiles. Detailed studies and clinical trials are essential to fully understand its safety and efficacy in medical applications.
| Catalog Number | I009267 |
| CAS Number | 151224-83-8 (free base) |
| Synonyms | S-8510; SB-737552; S8510; SB737552; S 8510; SB 737552.;2-(isoxazol-3-yl)-1,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine |
| Molecular Formula | C12H10N4O2 |
| Purity | ≥95% |
| Target | GABA-A receptor inverse agonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 4-(1,2-oxazol-3-yl)-12-oxa-3,5,8-triazatricyclo[7.4.0.02,6]trideca-1,3,6,8-tetraene |
| InChI | InChI=1S/C12H10N4O2/c1-3-17-6-7-8(1)13-5-10-11(7)15-12(14-10)9-2-4-18-16-9/h2,4-5H,1,3,6H2,(H,14,15) |
| InChIKey | ITPFSYAYHHPKRT-UHFFFAOYSA-N |
| SMILES | C1COCC2=C3C(=CN=C21)NC(=N3)C4=NOC=C4 |
| Reference | </br> 1:Chorvat RJ, Zaczek R, Brown BS. Ion channel modulators that enhance acetylcholine release: potential therapies for Alzheimer/’s disease. Expert Opin Investig Drugs. 1998 Apr;7(4):499-518. PubMed PMID: 15991988.</br> 2:Kominami G, Nakamura M, Chomei N, Takada S. Radioimmunoassay for a novel benzodiazepine inverse agonist, S-8510, in human plasma and urine. J Pharm Biomed Anal. 1999 Jun;20(1-2):145-53. PubMed PMID: 10704018.</br> 3: Tanaka H, Mizojiri K. Drug-protein binding and blood-brain barrier permeability. J Pharmacol Exp Ther. 1999 Mar;288(3):912-8. PubMed PMID: 10027826. |
