For research use only. Not for therapeutic Use.
Kv1.5 or IKur channel blocker, which suppresses both cloned (Kv1.5) and native (IKur) cardiac potassium current
| Catalog Number | I035911 |
| CAS Number | 332378-43-5 |
| Molecular Formula | C29H27N3O3 |
| Purity | ≥95% |
| IUPAC Name | benzyl N-[[2-[2-(2-pyridin-2-ylethylcarbamoyl)phenyl]phenyl]methyl]carbamate |
| InChI | InChI=1S/C29H27N3O3/c33-28(31-19-17-24-13-8-9-18-30-24)27-16-7-6-15-26(27)25-14-5-4-12-23(25)20-32-29(34)35-21-22-10-2-1-3-11-22/h1-16,18H,17,19-21H2,(H,31,33)(H,32,34) |
| SMILES | C1=CC=C(C=C1)COC(=O)NCC2=CC=CC=C2C3=CC=CC=C3C(=O)NCCC4=CC=CC=N4 |
| Reference | A Bachmann et al. Characterization of a novel Kv1.5 channel blocker in Xenopus oocytes, CHO cells, human and rat cardiomyocytes. Naunyn Schmiedebergs Arch Pharmacol. 2001, 364(5), 472-478.
K Knobloch et al. Electrophysiological and antiarrhythmic effects of the novel IKur channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the IKr blockers (…). Naunyn-Schmiedebergs Arch. Pharmacol. 2002, 366, 482. |
