For research use only. Not for therapeutic Use.
S-acetyl-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016484 |
| CAS Number | 1820641-93-7 |
| Synonyms | tert-butyl 3-[2-(2-acetylsulfanylethoxy)ethoxy]propanoate |
| Molecular Formula | C13H24O5S |
| Purity | ≥95% |
| InChI | InChI=1S/C13H24O5S/c1-11(14)19-10-9-17-8-7-16-6-5-12(15)18-13(2,3)4/h5-10H2,1-4H3 |
| InChIKey | DSBKYHJZFUGMFX-UHFFFAOYSA-N |
| SMILES | CC(=O)SCCOCCOCCC(=O)OC(C)(C)C |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
