For research use only. Not for therapeutic Use.
S-acetyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016482 |
| CAS Number | 1818294-26-6 |
| Synonyms | tert-butyl 3-[2-[2-[2-(2-acetylsulfanylethoxy)ethoxy]ethoxy]ethoxy]propanoate |
| Molecular Formula | C17H32O7S |
| Purity | ≥95% |
| InChI | InChI=1S/C17H32O7S/c1-15(18)25-14-13-23-12-11-22-10-9-21-8-7-20-6-5-16(19)24-17(2,3)4/h5-14H2,1-4H3 |
| InChIKey | KUEYETODKIHXFF-UHFFFAOYSA-N |
| SMILES | CC(=O)SCCOCCOCCOCCOCCC(=O)OC(C)(C)C |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
