(S)-BI 2536

• CAT Number: I047734
• CAS Number: 1241725-90-5
• Molecular Formula: C28H39N7O3
• Molecular Weight: 521.66
• Purity: ≥95%

(S)-BI 2536 is a dual PLK1 kinase/BRD4 bromodomain inhibitor with Ki values of 0.42 nM and 54 nM for PLK1 and BRD4, respectively. (S)-BI 2536 is the less active enantiomer of BI 2536 (Axon 1129, R-enantiomer).
KEYWORDS: (S)-BI 2536 | Supplier | PLK1/BRD4 inhibitor | (S)-BI2536 | (S)-BI-2536 | CAS [1241725-90-5] | Non Selective (CHK2 | p53) | Inhibitor

Reference

L Chen et al. BRD4 Structure-Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536. ACS Med Chem Lett. 2015 May 18;6(7):764-9.