(S)-Donepezil

• CAT Number: I026442
• CAS Number: 142057-80-5
• Molecular Formula: C24H29NO3
• Molecular Weight: 379.49
• Purity: ≥95%
• Synonyms: (2S)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
• InChI: InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3/t20-/m0/s1
• InChIKey: ADEBPBSSDYVVLD-FQEVSTJZSA-N
• SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC

(S)-Donepezil(CAT: I026442) is a chiral enantiomer of Donepezil, a well-known acetylcholinesterase (AChE) inhibitor used in the treatment of Alzheimer’s disease. Donepezil works by increasing acetylcholine levels in the brain, thereby enhancing cholinergic neurotransmission and improving cognitive function in patients with neurodegenerative disorders. While the marketed drug is the racemic mixture, the (S)-enantiomer may exhibit distinct pharmacokinetic or pharmacodynamic properties. Given its mechanism of action, (S)-Donepezil is most relevant to Neurological Disease Research, particularly in the study of Alzheimer’s disease, dementia, and other cognitive disorders associated with cholinergic dysfunction.