(S)-Donepezil

For research use only. Not for therapeutic Use.

  • CAT Number: I026442
  • CAS Number: 142057-80-5
  • Molecular Formula: C24H29NO3
  • Molecular Weight: 379.49
  • Purity: ≥95%
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(S)-Donepezil is a S-enantiomer of Donepezil (HY-14566). Donepezil is a specific and potent AChE inhibitor[1][2].


Catalog Number I026442
CAS Number 142057-80-5
Synonyms

(2S)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one

Molecular Formula C24H29NO3
Purity ≥95%
InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3/t20-/m0/s1
InChIKey ADEBPBSSDYVVLD-FQEVSTJZSA-N
SMILES COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
Reference

[1]. Lili W, et al. Steady-state plasma concentration of donepezil enantiomers and its stereoselective metabolism and transport in vitro. Chirality. 2013 Sep;25(9):498-505.
 [Content Brief]

[2]. Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13.
 [Content Brief]

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