(S)-Gossypol acetic acid

• CAT Number: I000679
• CAS Number: 1189561-66-7
• Molecular Formula: C32H34O10
• Molecular Weight: 578.61
• Purity: ≥95%
• Target: Bcl-2 Family
• Solubility: 10 mM in DMSO
• Storage: store at -20 ℃
• IC50: 18.1μM (Bcl-2), 22.9μM (Bcl-xL)
• IUPAC Name: acetic acid;7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde
• InChI: 1S/C30H30O8.C2H4O2/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36;1-2(3)4/h7-12,33-38H,1-6H3;1H3,(H,3,4)
• InChIKey: NIOHNDKHQHVLKA-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O.CC(=O)O

(S)-Gossypol acetic acid(CAT: I000679), also known as AT-101 or R-(-)-gossypol acetic acid, is a synthetic derivative of gossypol. Gossypol is a natural compound found in cottonseeds and has been studied for its potential anticancer properties. (S)-Gossypol acetic acid functions as a pan-inhibitor of Bcl-2 family proteins, which play a crucial role in regulating apoptosis (cell death) pathways. By inhibiting the anti-apoptotic proteins such as Bcl-2, Bcl-XL, and Mcl-1, (S)-Gossypol acetic acid can promote apoptosis in cancer cells, potentially inhibiting their growth and survival. It has shown promise in preclinical and clinical studies for various types of cancer and is being investigated as a potential therapeutic agent.