(S)-H-1152 dihydrochloride

• CAT Number: I003590
• CAS Number: 451462-58-1
• Molecular Formula: C₁₆H₂₁N₃O₂S.2HCl
• Molecular Weight: 392.34
• Purity: ≥95%
• Synonyms: (S)-4-methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline
• Target: TGF-beta/Smad
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 1.6 nM (Ki Value) [1]
• IUPAC Name: 4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline
• InChI: InChI=1S/C16H21N3O2S.2ClH/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2;;/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3;2*1H/t13-;;/m0../s1
• InChIKey: BFOPDSJOLUQULZ-GXKRWWSZSA-N
• SMILES: C[C@H]1CNCCCN1S(=O)(=O)C2=CC=CC3=C2C(=CN=C3)C

(S)-H-1152 Dihydrochloride(CAT: I003590) is a highly selective inhibitor of Rho-associated protein kinase (ROCK), with preferential activity against ROCK2. By targeting ROCK, it modulates cytoskeletal dynamics, reducing phosphorylation of myosin light chain and downstream effects such as stress fiber formation and cellular contractility. This compound is extensively utilized in research on cardiovascular diseases, cancer metastasis, and neurological disorders, where ROCK signaling plays a pivotal role. Its high specificity and potency make it an invaluable tool for studying the molecular mechanisms of ROCK-mediated pathways and for advancing therapeutic strategies targeting ROCK in pathological conditions.