(S)-Ketorolac

• CAT Number: R011272
• CAS Number: 66635-92-5
• Molecular Formula: C15H13NO3
• Molecular Weight: 255.273
• Purity: ≥95%
• Synonyms: (1S)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic Acid; (-)-Ketorolac; S-(-)-Ketorolac
• Target: COX
• Storage: -20°C
• IUPAC Name: (1S)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
• InChI: InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m0/s1
• InChIKey: OZWKMVRBQXNZKK-NSHDSACASA-N
• SMILES: C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O

(S)-Ketorolac is the active enantiomer of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) widely used for its potent analgesic and anti-inflammatory effects. Unlike its (R)-enantiomer, (S)-Ketorolac is primarily responsible for inhibiting cyclooxygenase (COX) enzymes, which reduces prostaglandin synthesis, thereby alleviating pain and inflammation. It is commonly employed in the treatment of moderate to severe pain, often postoperatively, providing an alternative to opioid analgesics. Due to its efficacy and non-narcotic nature, (S)-Ketorolac is a valuable option in pain management.