(S)-MCPG

• CAT Number: I001855
• CAS Number: 150145-89-4
• Molecular Formula: C10H11NO4
• Molecular Weight: 209.21
• Purity: ≥95%
• Synonyms: (R)-4-(1-amino-1-carboxyethyl)benzoic acid
• Target: Neuronal Signaling
• Solubility: DMSO ≥ 6.2 mg/mL
• Storage: Store at RT
• IUPAC Name: 4-[(1S)-1-amino-1-carboxyethyl]benzoic acid
• InChI: InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1
• InChIKey: DNCAZYRLRMTVSF-UHFFFAOYSA-N
• SMILES: C[C@](C1=CC=C(C=C1)C(=O)O)(C(=O)O)N

(S)-MCPG(CAT: I001855) (α-Methyl-4-carboxyphenylglycine) is a selective metabotropic glutamate receptor (mGluR) antagonist, primarily targeting group I (mGluR1 and mGluR5) and group II (mGluR2 and mGluR3) receptors. By inhibiting these receptors, (S)-MCPG modulates glutamatergic neurotransmission, which is crucial for synaptic plasticity, learning, and memory. It is widely used in neuroscience research to study mechanisms underlying long-term potentiation (LTP) and long-term depression (LTD) in the brain. (S)-MCPG is valuable for exploring the role of mGluRs in neurodegenerative diseases, epilepsy, and neuropathic pain, aiding in the development of targeted therapies for these conditions.