(S)-Remoxipride hydrochloride

• CAT Number: R049722
• CAS Number: 73220-03-8
• Molecular Formula: C16H24BrClN2O3
• Molecular Weight: 407.73
• Purity: ≥95%
• Synonyms: 3-bromo-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,6-dimethoxybenzamide;hydrochloride
• InChI: InChI=1S/C16H23BrN2O3.ClH/c1-4-19-9-5-6-11(19)10-18-16(20)14-13(21-2)8-7-12(17)15(14)22-3;/h7-8,11H,4-6,9-10H2,1-3H3,(H,18,20);1H/t11-;/m0./s1
• InChIKey: WCPXLMIPGMFZMY-MERQFXBCSA-N
• SMILES: CCN1CCCC1CNC(=O)C2=C(C=CC(=C2OC)Br)OC.Cl

(S)-Remoxipride ((-)-Remoxipride) hydrochloride is a selective dopamine D2-receptor antagonist with an IC50 value of 1.57 μM. (S)-Remoxipride hydrochloride can be used for the research of psychotic disorder[1].
(S)-Remoxipride hydrochloride (1-100 μM; 20 min) shows binding efficiency with IC50s of ＞100, 1.57 and 42 μM for dopamine D1, dopamine D2 and α1-Adrenoccptor, respectively[1].
(S)-Remoxipride hydrochloride (0.1-100 μM/kg; i.p. 60 min prior to apomorphine) blockades apomorphine-induced behaviors s in rats and vomiting in dogs[1].
(S)-Remoxipride hydrochloride (0.1-10 mg/kg; i.p. 30 min prior to apomorphine) displaces [3H]spiperone from both striatal and extra-striatal areas[1].