(S)-(+)-Rolipram

• CAT Number: I005129
• CAS Number: 85416-73-5
• Molecular Formula: C16H21NO3
• Molecular Weight: 275.34
• Purity: ≥95%
• Synonyms: (4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
• Target: PDE
• Solubility: DMSO 55 mg/mL; Water <1 mg/mL
• Storage: Sealed in dry,Store in freezer, under -20°C
• InChI: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
• InChIKey: HJORMJIFDVBMOB-GFCCVEGCSA-N
• SMILES: COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

(S)-(+)-Rolipram（Cat No.:I005129）is a selective phosphodiesterase-4 (PDE4) inhibitor, recognized for its role in increasing intracellular cyclic AMP (cAMP) levels. By blocking PDE4, (S)-(+)-Rolipram enhances cAMP signaling, which can lead to anti-inflammatory and neuroprotective effects. This compound has been studied for potential therapeutic applications in treating depression, neuroinflammation, and autoimmune disorders. Due to its effects on the central nervous system, (S)-(+)-Rolipram is also used as a research tool to explore cAMP-related pathways in neurobiology and immune response modulation, offering insights into novel therapeutic strategies.

Reference

[1]. Griswold, D.E., et al., Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation, 1993. 17(3): p. 333-44.
[2]. Zhu, J., E. Mix, and B. Winblad, The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev, 2001. 7(4): p. 387-98.