(S)-Seco-Duocarmycin SA

• CAT Number: I017810
• CAS Number: 152785-82-5
• Molecular Formula: C₂₅H₂₄ClN₃O₇
• Molecular Weight: 513.93
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: methyl (8S)-8-(chloromethyl)-4-hydroxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-7,8-dihydro-3H-pyrrolo[3,2-e]indole-2-carboxylate
• InChI: InChI=1S/C25H24ClN3O7/c1-33-18-6-11-5-14(27-20(11)23(35-3)22(18)34-2)24(31)29-10-12(9-26)19-13-7-15(25(32)36-4)28-21(13)17(30)8-16(19)29/h5-8,12,27-28,30H,9-10H2,1-4H3/t12-/m1/s1
• InChIKey: SDJNZXKVYYJDDM-GFCCVEGCSA-N
• SMILES: COC1=C(C(=C2C(=C1)C=C(N2)C(=O)N3CC(C4=C5C=C(NC5=C(C=C43)O)C(=O)OC)CCl)OC)OC

(S)-Seco-Duocarmycin SA（Cat No.:I017810） is a potent DNA alkylating agent and cytotoxin used in antibody drug conjugates (ADCs). It is designed to selectively target cancer cells by binding to specific cell surface antigens and delivering the toxic payload directly to the tumor cells. (S)-Seco-Duocarmycin SA forms covalent bonds with DNA, leading to DNA damage and inhibition of DNA replication and transcription, ultimately resulting in cell death.

Reference

[1]. Tichenor MS, et al. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. J Am Chem Soc. 2007 Sep 5;129(35):10858-69.