For research use only. Not for therapeutic Use.
(S)-SNAP5114 is a selective GABA transport inhibitor, with IC50 values of 5 μM and 21 μM for hGAT-3 and rGAT-2, respectively. (S)-SNAP5114 is an anticonvulsant agent[1][2].
| Catalog Number | M099814 |
| CAS Number | 157604-55-2 |
| Synonyms | (3S)-1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid |
| Molecular Formula | C30H35NO6 |
| Purity | ≥95% |
| InChI | InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1 |
| InChIKey | VDLDUZLDZBVOAS-QFIPXVFZSA-N |
| SMILES | COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)OCCN4CCCC(C4)C(=O)O |
| Reference | [1]. Borden LA, et al. Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels. 1994;2(3):207-13. [2]. Borden LA, et al. GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem Int. 1996 Oct;29(4):335-56. |
