(S)-Trolox

• CAT Number: I017499
• CAS Number: 53174-06-4
• Molecular Formula: C₁₄H₁₈O₄
• Molecular Weight: 250.29
• Purity: ≥95%
• IUPAC Name: (2S)-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid
• InChI: 1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)/t14-/m0/s1
• InChIKey: GLEVLJDDWXEYCO-AWEZNQCLSA-N
• SMILES: CC1=C(C2=C(CC[C@@](O2)(C)C(=O)O)C(=C1O)C)C

(S)-Trolox (Cat No.: I017499) is a chiral analog of Trolox, a water-soluble derivative of vitamin E known for its potent antioxidant properties. The (S)-enantiomer specifically scavenges reactive oxygen species (ROS) and protects cells from oxidative stress-induced damage. It is widely used in biochemical and pharmacological research to study enantioselective antioxidant mechanisms and cellular redox regulation. (S)-Trolox is valuable in exploring oxidative stress-related diseases, such as neurodegenerative disorders, cardiovascular conditions, and cancer, and serves as a reference compound in antioxidant activity assays.

Reference

[1]. Malcolm CS, et al. Characterization of iodoacetate-mediated neurotoxicity in vitro using primary cultures of rat cerebellar granule cells. Free Radic Biol Med. 2000 Jan 1;28(1):102-7.[2]. Górecki M, et al. Chromane helicity rule–scope and challenges based on an ECD study of various trolox derivatives. Org Biomol Chem. 2014 Apr 14;12(14):2235-54.