(S)-(-)-Verapamil Hydrochloride

• CAT Number: R007244
• CAS Number: 36622-28-3
• Molecular Formula: C₂₇H₃₉ClN₂O₄
• Molecular Weight: 491.06
• Purity: ≥95%
• Synonyms: (αS)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-benzeneacetonitrile Hydrochloride; (S)-Verapamil Hydrochloride; (-)-Verapamil Hydrochloride
• Storage: -20°C
• IUPAC Name: (2S)-2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride
• InChI: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H/t27-;/m0./s1
• InChIKey: DOQPXTMNIUCOSY-YCBFMBTMSA-N
• SMILES: CC(C)[C@](CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

(S)-(-)-Verapamil Hydrochloride（Cat No.:R007244）is the enantiomer of verapamil, a calcium channel blocker primarily used to treat hypertension, angina, and certain types of arrhythmias. By inhibiting L-type calcium channels, it reduces calcium influx into cardiac and smooth muscle cells, leading to vasodilation and a decrease in heart rate and contractility. The (S)-(-)-enantiomer is more potent in its effects on the cardiovascular system, particularly in antiarrhythmic applications. (S)-(-)-Verapamil Hydrochloride is widely used in both clinical and research settings to explore enantiomer-specific pharmacological effects.