(S)-VU0637120

• CAT Number: I047670
• CAS Number: 1175940-86-9
• Molecular Formula: C16H19N3O5S2
• Molecular Weight: 397.47
• Purity: ≥95%
• IUPAC Name: (2S)-N-(6,7-dihydro-[1,4]dioxino[2,3-f][1,3]benzothiazol-2-yl)-1-methylsulfonylpiperidine-2-carboxamide
• InChI: InChI=1S/C16H19N3O5S2/c1-26(21,22)19-5-3-2-4-11(19)15(20)18-16-17-10-8-12-13(9-14(10)25-16)24-7-6-23-12/h8-9,11H,2-7H2,1H3,(H,17,18,20)/t11-/m0/s1
• SMILES: CS(=O)(=O)N1CCCC[C@H]1C(=O)NC2=NC3=CC4=C(C=C3S2)OCCO4

(S)-VU0637120 is a first-in-class, selective neuropeptide Y4 receptor allosteric antagonist with an IC50 value of 2.7 μM. (S)-VU0637120 selectively inhibits native Y4R function and binds in an allosteric site located below the binding pocket of the endogenous ligand pancreatic polypeptide in the core of the Y4R transmembrane domains.
KEYWORDS: (S)-VU0637120 | Supplier | Y4R allosteric antagonist | (S)-VU 0637120 | (S)-VU-0637120 | CAS [1175940-86-9] | Neuropeptide Y | Antagonist | Receptors | Metabolic disease | Anorexia | Obesity

Reference

C Schüß et al. Highly Selective Y4 Receptor Antagonist Binds in an Allosteric Binding Pocket. J Med Chem. 2021 Mar 11;64(5):2801-2814.