(S)-Willardiine

• CAT Number: I002646
• CAS Number: 21416-43-3
• Molecular Formula: C7H9N3O4
• Molecular Weight: 199.16
• Purity: ≥95%
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 44.8 uM(EC50) [1]

(S)-Willardiine (Cat.No:I002646) is a chemical compound that acts as an agonist of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype of glutamate receptors. It is widely used in neuroscientific research to study excitatory neurotransmission and the functions of AMPA receptors in the central nervous system. (S)-Willardiine has valuable applications in studying neuronal physiology and synaptic plasticity.

Reference

[1]. Patneau DK, et al. Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J Neurosci. 1992 Feb;12(2):595-606.
[2]. Fukushima T, et al. Calcium inhibits willardiine-induced responses in kainate receptor GluR6(Q)/KA-2. Neuroreport. 2001 Jan 22;12(1):163-7.
[3]. Gressens P, et al. The effects of AMPA receptor antagonists in models of stroke and neurodegeneration. Eur J Pharmacol. 2005 Sep 5;519(1-2):58-67.