(S)-ZINC-3573

• CAT Number: I015371
• CAS Number: 2095596-11-3
• Molecular Formula: C18H21N5
• Molecular Weight: 307.39
• Purity: ≥95%
• Synonyms: (3S)-N,N-dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-3-amine
• InChI: InChI=1S/C18H21N5/c1-21(2)15-9-11-22(13-15)18-12-16(14-6-4-3-5-7-14)20-17-8-10-19-23(17)18/h3-8,10,12,15H,9,11,13H2,1-2H3/t15-/m0/s1
• InChIKey: XKBSPAZCFAIBJL-HNNXBMFYSA-N
• SMILES: CN(C)C1CCN(C1)C2=CC(=NC3=CC=NN32)C4=CC=CC=C4

(S)-ZINC-3573 is an inactive enantiomer of ZINC-3573. (R)-ZINC-3573 is a selective MRGPRX2 agonist. (S)-ZINC-3573 and (R)-ZINC3573 are effective and internally controlled probe-pairs for investigating the biology of primate-exclusive receptor[1].
(S)-ZINC-3573 displays no activity on MRGPRX2 at concentrations below 100 μM[1].
(R)-ZINC-3573阴性对照

Reference

[1]. Katherine Lansu, et al. In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat Chem Biol. 2017 May;13(5):529-536.
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