For research use only. Not for therapeutic Use.
S107 (CAT: I009246) emerges as a notable compound with a specific mode of action involving the ryanodine receptor type 1 (RyR1), a key player in intracellular calcium release. S107 acts as a RyR1 stabilizer by binding to the receptor and enhancing the binding affinity of calstabin-1, a regulatory protein associated with RyR1 function. Through this interaction, S107 effectively inhibits the leakage of calcium ions from the sarcoplasmic reticulum (SR), a process that contributes to muscle contraction and relaxation.
| Catalog Number | I009246 |
| CAS Number | 927871-76-9 |
| Synonyms | S107; S-107; S 107.;2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine |
| Molecular Formula | C11H16ClNOS |
| Purity | 95% |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| InChI | InChI=1S/C11H15NOS.ClH/c1-12-5-6-14-11-4-3-10(13-2)7-9(11)8-12;/h3-4,7H,5-6,8H2,1-2H3;1H |
| InChIKey | PKLKSAHANRLKJK-UHFFFAOYSA-N |
| SMILES | CN1CCSC2=CC=C(OC)C=C2C1.[H]Cl |
| Reference | </br>1:Mei Y, Xu L, Kramer HF, Tomberlin GH, Townsend C, Meissner G. Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107. PLoS One. 2013;8(1):e54208. doi: 10.1371/journal.pone.0054208. Epub 2013 Jan 17. PubMed PMID: 23349825; PubMed Central PMCID: PMC3547879.</br>2:Kreko-Pierce T, Azpurua J, Mahoney RE, Eaton BA. Extension of Health Span and Life Span in Drosophila by S107 Requires the calstabin Homologue FK506-BP2. J Biol Chem. 2016 Dec 9;291(50):26045-26055. Epub 2016 Nov 1. PubMed PMID: 27803160; PubMed Central PMCID: PMC5207075. |
