S119-8

• CAT Number: I020022
• CAS Number: 443639-96-1
• Molecular Formula: C₂₃H₂₄N₂O
• Molecular Weight: 344.45
• Purity: ≥95%
• Target: Influenza Virus
• IUPAC Name: N-(4-anilinophenyl)-4-tert-butylbenzamide
• InChI: InChI=1S/C23H24N2O/c1-23(2,3)18-11-9-17(10-12-18)22(26)25-21-15-13-20(14-16-21)24-19-7-5-4-6-8-19/h4-16,24H,1-3H3,(H,25,26)
• InChIKey: NEPKMQDGCTXOPG-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)NC3=CC=CC=C3

S119-8（Cat No.:I020022）is a broad-spectrum inhibitor targeting influenza A and B viruses by disrupting the viral nucleoprotein (NP), which is essential for viral replication. It demonstrates activity against multiple influenza B strains and oseltamivir-resistant influenza A strains, with an IC50 of 1.43 μM and a CC50 of 66.10 μM, indicating significant potency at non-toxic concentrations. Notably, S119-8 does not inhibit non-influenza viruses like vesicular stomatitis virus (VSV). Its unique mechanism and efficacy make it a promising candidate for developing new antiviral therapies.

Reference

[1]. White KM, et al. Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. ACS Infect Dis. 2018 Feb 9;4(2):146-157.