S130

• CAT Number: I019089
• CAS Number: 1160852-22-1
• Molecular Formula: C₂₄H₂₅N₃O₂
• Molecular Weight: 387.47
• Purity: ≥95%
• Target: Autophagy
• IUPAC Name: N-[3-(diethylamino)propyl]-8-oxo-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9,11,13(17),14-octaene-12-carboxamide
• InChI: InChI=1S/C24H25N3O2/c1-3-27(4-2)14-8-13-25-24(29)20-15-26-22-21-17(11-7-12-18(20)21)16-9-5-6-10-19(16)23(22)28/h5-7,9-12,15H,3-4,8,13-14H2,1-2H3,(H,25,29)
• InChIKey: DZUCZYXRADUTMW-UHFFFAOYSA-N
• SMILES: CCN(CC)CCCNC(=O)C1=CN=C2C3=C1C=CC=C3C4=CC=CC=C4C2=O

S130（Cat No.:I019089）is a potent small-molecule inhibitor primarily targeting phosphodiesterase 4 (PDE4), an enzyme involved in the breakdown of cyclic AMP (cAMP). By inhibiting PDE4, S130 elevates intracellular cAMP levels, leading to anti-inflammatory effects that are valuable in studying immune modulation and potential therapeutic approaches for inflammatory diseases. Its selectivity for PDE4 has made it a candidate in research on respiratory disorders, neuroinflammation, and autoimmune conditions. S130’s mechanism offers insights into PDE4’s role in disease pathways, supporting advancements in inflammation-focused pharmacology and therapeutic exploration.

Reference

[1]. Fu Y, et al. Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo. Autophagy. 2018 Sep 20:1-17.