S1R agonist 2

• CAT Number: I041189
• CAS Number: 150085-21-5
• Molecular Formula: C21H27NO
• Molecular Weight: 309.45
• Purity: ≥95%
• Synonyms: 4-benzyl-1-(3-phenoxypropyl)piperidine
• InChI: InChI=1S/C21H27NO/c1-3-8-19(9-4-1)18-20-12-15-22(16-13-20)14-7-17-23-21-10-5-2-6-11-21/h1-6,8-11,20H,7,12-18H2
• InChIKey: KOYQYIAABUPJFF-UHFFFAOYSA-N
• SMILES: C1CN(CCC1CC2=CC=CC=C2)CCCOC3=CC=CC=C3

S1R agonist 2 (Compound 8b) is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1].
S1R agonist 2 (Compound 8b; 0.1-5 μM) significantly increases the nerve growth factor (NGF) induced neurite outgrowth at all the tested concentrations in a dose-dependent manner[1].
S1R agonist 2 (24 h) significantly prevents cell damage induced by Rotenone (HY-B1756) when tested at the concentration of 1 μM in SHSY5Y cells[1].
S1R agonist 2 (0.1-5 μM; 24 h) demonstrates a neuroprotective effect against NMDA stimuli in SHSY5Y cells[1].
S1R agonist 2 (0-10 μM; 24-72 h) shows no cytotoxicity against A549, LoVo and Panc-1 cells[1].
S1R agonist 2 (Compound 8b; 0.1-50 μM; 120 h) does not induce embryo death (100% of embryos alive) at 10 μM, but induces the death of all zebrafish embryo at the highest dose tested (50 μM)[1].

Reference

[1]. Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163.
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