For research use only. Not for therapeutic Use.
S38093 HCl (CAT: I014668) is a compound that acts as an inverse agonist at histamine H3 receptors. It possesses a moderate affinity for histamine H3 receptors in rats, mice, and humans. By acting as an inverse agonist, S38093 HCl has the potential to modulate the activity of these receptors, which are involved in regulating neurotransmitter release and other physiological processes. Its ability to bind to and affect histamine H3 receptors makes S38093 HCl an important tool in the study of histamine receptor signaling and related physiological pathways.
| Catalog Number | I014668 |
| CAS Number | 1222097-72-4 (HCl) |
| Synonyms | S 38093; S38093; S-38093; S38093 HCl;4-(3-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy)benzamide hydrochloride |
| Molecular Formula | C17H25ClN2O2 |
| Purity | ≥95% |
| Target | brain-penetrant antagonist |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C17H24N2O2.ClH/c18-17(20)13-5-7-16(8-6-13)21-10-2-9-19-11-14-3-1-4-15(14)12-19;/h5-8,14-15H,1-4,9-12H2,(H2,18,20);1H |
| InChIKey | AFSVOZDCVFYWFG-UHFFFAOYSA-N |
| SMILES | O=C(N)C(C=C1)=CC=C1OCCCN2CC3CCCC3C2.Cl |
| Reference | </br>1: Guilloux JP, Samuels BA, Mendez-David I, Hu A, Levinstein M, Faye C, Mekiri M, Mocaer E, Gardier AM, Hen R, Sors A, David DJ. S 38093, a histamine H(3) antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci Rep. 2017 Feb 20;7:42946. doi: 10.1038/srep42946. PubMed PMID: 28218311; PubMed Central PMCID: PMC5317168.</br>2: Sors A, Panayi F, Bert L, Favale D, Nosjean O, Audinot V, Arrang JM, Buisson B, Steidl E, Delbos JM, Huhtala T, Kontkanen O, Chollet AM, Casara P, Lestage P. Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors. Eur J Pharmacol. 2017 May 15;803:11-23. doi: 10.1016/j.ejphar.2017.03.013. Epub 2017 Mar 21. PubMed PMID: 28336400.</br>3: Sors A, Krazem A, Kehr J, Yoshitake T, Dominguez G, Henkous N, Letondor C, Mocaer E, Béracochéa DJ. The Synergistic Enhancing-Memory Effect of Donepezil and S 38093 (a Histamine H(3) Antagonist) Is Mediated by Increased Neural Activity in the Septo-hippocampal Circuitry in Middle-Aged Mice. Front Pharmacol. 2016 Dec 22;7:492. doi: 10.3389/fphar.2016.00492. eCollection 2016. PubMed PMID: 28066242; PubMed Central PMCID: PMC5177663.</br>4: Panayi F, Sors A, Bert L, Martin B, Rollin-Jego G, Billiras R, Carrié I, Albinet K, Danober L, Rogez N, Thomas JY, Pira L, Bertaina-Anglade V, Lestage P. In vivo pharmacological profile of S 38093, a novel histamine H3 receptor inverse agonist. Eur J Pharmacol. 2017 May 15;803:1-10. doi: 10.1016/j.ejphar.2017.03.008. Epub 2017 Mar 14. PubMed PMID: 28315340.</br>5: Mahaffey DT, Peeler JS, Brodsky FM, Anderson RG. Clathrin-coated pits contain an integral membrane protein that binds the AP-2 subunit with high affinity. J Biol Chem. 1990 Sep 25;265(27):16514-20. PubMed PMID: 1975814.</br></br> |
