For research use only. Not for therapeutic Use.
S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC50=1.7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation[1].
S3QELs-2 protects against ROS-induced, JNK-mediated cell stress in pancreatic β-cells and S3QEL-2 strongly mitigates the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets[1].
| Catalog Number | R032757 |
| CAS Number | 890888-12-7 |
| Synonyms | 1-(3,4-dimethylphenyl)-N,N-dipropylpyrazolo[3,4-d]pyrimidin-4-amine |
| Molecular Formula | C19H25N5 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H25N5/c1-5-9-23(10-6-2)18-17-12-22-24(19(17)21-13-20-18)16-8-7-14(3)15(4)11-16/h7-8,11-13H,5-6,9-10H2,1-4H3 |
| InChIKey | MGIAJZSCNPODRR-UHFFFAOYSA-N |
| SMILES | CCCN(CCC)C1=NC=NC2=C1C=NN2C3=CC(=C(C=C3)C)C |
| Reference | [1]. Orr AL, et al. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015;11(11):834-836. |
