SA-15-P

• CAT Number: I047713
• CAS Number: 852846-00-5
• Molecular Formula: C26H24N2O4
• Molecular Weight: 428.48
• Purity: ≥95%
• IUPAC Name: N-[4-[2-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethoxy]phenyl]furan-2-carboxamide
• InChI: InChI=1S/C26H24N2O4/c1-18-15-23(19(2)28(18)16-20-7-4-3-5-8-20)24(29)17-32-22-12-10-21(11-13-22)27-26(30)25-9-6-14-31-25/h3-15H,16-17H2,1-2H3,(H,27,30)
• SMILES: CC1=CC(=C(N1CC2=CC=CC=C2)C)C(=O)COC3=CC=C(C=C3)NC(=O)C4=CC=CO4

SA-15-P is a first-in-class inhibitor of lymphocyte activation gene 3 (LAG-3) with IC50 values of 4.21 and 6.52 μM for LAG-3/MHCII and LAG-3/FGL1 interactions, respectively.
Keywords: SA-15-P | Supplier | LAG-3 inhibitor | SA15-P | SA 15-P | CAS [852846-00-5] | MHC class II | FGL1 | LAG-3 | Inhibitor | Receptors | Negative immune checkpoint | Immuno-oncology | Immunomodulator | Cancer immunotherapy | CD223 | Immune checkpoint receptor

Reference

SA Abdel-Rahman et al. Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3). ACS Med Chem Lett. 2023 Apr 11;14(5):629-635.