SA4503 dihydrochloride

• CAT Number: I002163
• CAS Number: 165377-44-6
• Molecular Formula: C23H32N2O2.2HCl
• Molecular Weight: 441.43
• Purity: ≥95%
• Synonyms: 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
• Target: Sigma Receptor
• Solubility: DMSO ＜ 10.4 mg/mL
• Storage: Store at RT
• IC50: 17.4 nM [1]
• IUPAC Name: 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine;dihydrochloride
• InChI: InChI=1S/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H
• InChIKey: XWOXAKBQEMQMFH-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)CCN2CCN(CC2)CCCC3=CC=CC=C3)OC.Cl.Cl

SA4503 dihydrochloride (Cat.No:I002163) is a chemical compound with potential neuroprotective and neuromodulatory effects. It acts as a selective sigma-1 receptor agonist, a protein involved in various cellular processes and neuroprotection. SA4503 dihydrochloride has been studied for its potential therapeutic applications in neurodegenerative disorders and as a candidate for drug development.

Reference

[1]. Matsuno K, et al. Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur J Pharmacol. 1996 Jun 13;306(1-3):271-9.
[2]. Minabe Y, et al. Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study. Synapse. 1999 Aug;33(2):129-40.
[3]. Ono Y, et al. SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models. Neurosci Lett. 2014 Jan 24;559:174-8.