For research use only. Not for therapeutic Use.
Sabcomeline (SB-202026) hydrochloride is a potent and functionally selective muscarinic M1 receptor partial agonist that improve cognition. Sabcomeline hydrochloride can be used for Alzheimer’s disease research[1][2].
| Catalog Number | I009270 |
| CAS Number | 159912-58-0 |
| Synonyms | (3Z,3R)-N-methoxy-1-azabicyclo[2.2.2]octane-3-carboximidoyl cyanide;hydrochloride |
| Molecular Formula | C10H16ClN3O |
| Purity | ≥95% |
| InChI | InChI=1S/C10H15N3O.ClH/c1-14-12-10(6-11)9-7-13-4-2-8(9)3-5-13;/h8-9H,2-5,7H2,1H3;1H/b12-10+;/t9-;/m0./s1 |
| InChIKey | INJWRVWKJFJRFO-SCRZZQONSA-N |
| SMILES | CON=C(C#N)C1CN2CCC1CC2.Cl |
| Reference | [1]. Hosoi R, Kobayashi K, Ishida J, Yamaguchi M, Inoue O. Effect of sabcomeline on muscarinic and dopamine receptor binding in intact mouse brain. Ann Nucl Med. 2003;17(2):123-130. [2]. Hatcher JP, Loudon JM, Hagan JJ, Clark MS. Sabcomeline (SB-202026), a functionally selective M1 receptor partial agonist, reverses delay-induced deficits in the T-maze. Psychopharmacology (Berl). 1998;138(3-4):275-282. |
