For research use only. Not for therapeutic Use.
Saccharin 1-methylimidazole is an activator for DNA/RNA Synthesis.
Exposure to certain concentrations of the entirely different promoters phenobarbital and the calcium and sodium salts of saccharin (22, 23, 25, 29, 38) stimulates calcium-deprived T51B cells to initiate DNA synthesis as rapidly and as effectively, or nearly as effectively, as raising the extracellular calcium concentration to 1.25 mM[1].
| Catalog Number | I012006 |
| CAS Number | 482333-74-4 |
| Synonyms | 1,1-dioxo-1,2-benzothiazol-3-one;1-methylimidazole |
| Molecular Formula | C11H11N3O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C7H5NO3S.C4H6N2/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;1-6-3-2-5-4-6/h1-4H,(H,8,9);2-4H,1H3 |
| InChIKey | DMSNKRPEUQVMNF-UHFFFAOYSA-N |
| SMILES | CN1C=CN=C1.C1=CC=C2C(=C1)C(=O)NS2(=O)=O |
| Reference | [1]. Boynton AL, et al. Stimulation of DNA synthesis in calcium-deprived T51B liver cells by the tumor promoters phenobarbital, saccharin, and 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 1980 Dec;40(12):4541-5. |
