For research use only. Not for therapeutic Use.
Saclofen is a competitive antagonist of the GABAB receptor with an IC50 of 7.8 μM. Saclofen can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain[1].
| Catalog Number | R026139 |
| CAS Number | 125464-42-8 |
| Synonyms | 3-amino-2-(4-chlorophenyl)propane-1-sulfonic acid |
| Molecular Formula | C9H12ClNO3S |
| Purity | ≥95% |
| InChI | InChI=1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14) |
| InChIKey | JYLNVJYYQQXNEK-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C(CN)CS(=O)(=O)O)Cl |
| Reference | [1]. Sallam MY, et al. Central GABAA receptors are involved in inflammatory and cardiovascular consequences of endotoxemia in conscious rats. Naunyn Schmiedebergs Arch Pharmacol. 2016 Mar;389(3):279-88. |
