Sacubitril sodium

• CAT Number: I009272
• CAS Number: 149690-05-1
• Molecular Formula: C24H28NNaO5
• Molecular Weight: 433.47
• Purity: ≥95%
• Synonyms: sodium;4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate
• InChI: InChI=1S/C24H29NO5.Na/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);/q;+1/p-1/t17-,21+;/m1./s1
• InChIKey: RRTBVEJIZWGATF-JKSHRDEXSA-M
• SMILES: CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].[Na+]

Sacubitril sodium（Cat No.:I009272）is a medication used in combination with valsartan to treat heart failure with reduced ejection fraction (HFrEF). It is a prodrug of sacubitril, which inhibits neprilysin, an enzyme responsible for degrading natriuretic peptides. By inhibiting neprilysin, sacubitril enhances the levels of these peptides, leading to vasodilation, reduced blood pressure, and improved fluid balance. This mechanism helps reduce the strain on the heart and improves symptoms of heart failure. Sacubitril sodium, when combined with valsartan, improves outcomes in heart failure patients by addressing both neurohormonal and volume overload factors.