For research use only. Not for therapeutic Use.
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice[1].
SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC–induced calcium mobilization with an IC50 value below 50 nM[1].
SAE-14 (compound SAE-14) (i.th.; 2.9 µM; once) can reverse nerve injury-induced allodynia in mice[1].
| Catalog Number | I043430 |
| CAS Number | 1241280-25-0 |
| Synonyms | 3-(3,4-difluorophenyl)-N-(3-fluoro-5-morpholin-4-ylphenyl)propanamide |
| Molecular Formula | C19H19F3N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H19F3N2O2/c20-14-10-15(12-16(11-14)24-5-7-26-8-6-24)23-19(25)4-2-13-1-3-17(21)18(22)9-13/h1,3,9-12H,2,4-8H2,(H,23,25) |
| InChIKey | SIVJKYRAPQKLIM-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=CC(=CC(=C2)NC(=O)CCC3=CC(=C(C=C3)F)F)F |
| Reference | [1]. Kathryn Braden, et al. GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain. J Pharmacol Exp Ther. 2020 Nov;375(2):367-375. |
