SAE-14

• CAT Number: I043430
• CAS Number: 1241280-25-0
• Molecular Formula: C19H19F3N2O2
• Molecular Weight: 364.36
• Purity: ≥95%
• Synonyms: 3-(3,4-difluorophenyl)-N-(3-fluoro-5-morpholin-4-ylphenyl)propanamide
• InChI: InChI=1S/C19H19F3N2O2/c20-14-10-15(12-16(11-14)24-5-7-26-8-6-24)23-19(25)4-2-13-1-3-17(21)18(22)9-13/h1,3,9-12H,2,4-8H2,(H,23,25)
• InChIKey: SIVJKYRAPQKLIM-UHFFFAOYSA-N
• SMILES: C1COCCN1C2=CC(=CC(=C2)NC(=O)CCC3=CC(=C(C=C3)F)F)F

SAE-14（Cat No.:I043430）is a small molecule inhibitor that targets the enzyme SUMO-activating enzyme (SAE), which is involved in the process of protein sumoylation. SUMOylation is a post-translational modification that regulates various cellular processes such as protein stability, localization, and activity. By inhibiting SAE, SAE-14 disrupts the sumoylation process, which can affect multiple signaling pathways and cellular functions. This compound is being investigated for its potential therapeutic applications in cancer, neurodegenerative diseases, and other conditions where abnormal sumoylation contributes to disease progression, offering a novel approach to modulating cellular functions for therapeutic benefit.