For research use only. Not for therapeutic Use.
SAFit1 (Cat.No:I019685) is a chemical compound with potential applications in cancer research. It is a small molecule inhibitor that selectively targets the transcription factor Stat3 (Signal Transducer and Activator of Transcription 3). Stat3 plays a crucial role in cancer cell survival and proliferation, making SAFit1 a promising candidate for developing anticancer therapies.
| Catalog Number | I019685 |
| CAS Number | 1643125-32-9 |
| Molecular Formula | C₄₂H₅₃NO₁₁ |
| Purity | ≥95% |
| Target | Immunology/Inflammation |
| IUPAC Name | 2-[3-[(1R)-1-[(2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid |
| InChI | 1S/C42H53NO11/c1-48-34-20-18-27(22-35(34)49-2)17-19-33(29-14-11-15-31(23-29)53-26-38(44)45)54-42(47)32-16-9-10-21-43(32)41(46)39(28-12-7-6-8-13-28)30-24-36(50-3)40(52-5)37(25-30)51-4/h11,14-15,18,20,22-25,28,32-33,39H,6-10,12-13,16-17,19,21,26H2,1-5H3,(H,44,45)/t32-,33+,39-/m0/s1 |
| InChIKey | OEQZPFWOEOOISR-AKTKKGGCSA-N |
| SMILES | COC1=C(C=C(C=C1)CC[C@H](C2=CC(=CC=C2)OCC(=O)O)OC(=O)[C@@H]3CCCCN3C(=O)[C@@H](C4CCCCC4)C5=CC(=C(C(=C5)OC)OC)OC)OC |
| Reference | [1]. Gaali S, et al. Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat Chem Biol. 2015 Jan;11(1):33-7.<br>[2]. Sidibeh CO, et al. FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes. Endocrine. 2018 Oct;62(1):116-128. |
