SAG Dihydrochloride

• CAT Number: I012245
• CAS Number: 364590-63-6
• Molecular Formula: C28H32Cl3N3O2S
• Molecular Weight: 580.99
• Purity: ≥95%
• Synonyms: 3-Chloro-benzo[b]thiophene-2-carboxylic acid (4-methylamino-cyclohexyl)-(3-pyridin-4-yl-benzyl)-amide Hydrochloride hydrate
• IUPAC Name: 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide;hydrate;dihydrochloride
• InChI: InChI=1S/C28H28ClN3OS.2ClH.H2O/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20;;;/h2-8,13-17,22-23,30H,9-12,18H2,1H3;2*1H;1H2
• InChIKey: IYXUQUYRWPGIQL-UHFFFAOYSA-N
• SMILES: CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl.O.Cl.Cl

SAG Dihydrochloride (Cat No.:I012245) is a chemical compound often used in biochemical research, particularly in the study of signaling pathways involving the Hedgehog (Hh) pathway. It functions as an inhibitor of the Smoothened (Smo) protein, a key component in this signaling cascade. By blocking Smo, SAG Dihydrochloride can modulate the activity of Hh signaling, which is involved in various developmental processes and diseases, including cancer. SAG Dihydrochloride is typically used in cell culture experiments to investigate the molecular mechanisms of Hh-related diseases and to explore potential therapeutic strategies.