SAHA

• CAT Number: A000479
• CAS Number: 149647-78-9
• Molecular Formula: C₁₄H₂₀N₂O₃
• Molecular Weight: 264.30
• Purity: ≥95%
• Synonyms: 149647-78-9; SAHA; Suberoylanilide hydroxamic acid; Zolinza; N-hydroxy-N/’-phenyloctanediamide
• Target: HDAC
• Solubility: >4.4mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: N'-hydroxy-N-phenyloctanediamide
• InChI: InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
• InChIKey: WAEXFXRVDQXREF-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

SAHA (Cat No.:A000479), also known as Vorinostat, is a histone deacetylase (HDAC) inhibitor approved for treating cutaneous T-cell lymphoma. By inhibiting HDACs, SAHA promotes the acetylation of histones and non-histone proteins, leading to changes in gene expression that can induce cell cycle arrest, differentiation, and apoptosis in cancer cells. Its broad-spectrum activity against various cancer types makes it a valuable tool in oncology. Ongoing research is exploring its efficacy in combination therapies and its potential applications in other malignancies, highlighting its role in epigenetic cancer treatments.

Reference

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