Sal003

• CAT Number: I000592
• CAS Number: 1164470-53-4
• Molecular Formula: C18H15Cl4N3OS
• Molecular Weight: 463.21
• Purity: ≥95%
• Synonyms: (E)-3-phenyl-N-[2,2,2-trichloro-1-[(4-chlorophenyl)carbamothioylamino]ethyl]prop-2-enamide
• Target: Protein Ser/Thr Phosphatases
• Solubility: DMSO > 10 mg/ml
• Storage: Store at -20°C
• InChI: InChI=1S/C18H15Cl4N3OS/c19-13-7-9-14(10-8-13)23-17(27)25-16(18(20,21)22)24-15(26)11-6-12-4-2-1-3-5-12/h1-11,16H,(H,24,26)(H2,23,25,27)/b11-6+
• InChIKey: TVNBASWNLOIQML-IZZDOVSWSA-N
• SMILES: C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=C(C=C2)Cl

Sal003（Cat No.:I000592）is a potent, small-molecule inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A), enzymes involved in the dephosphorylation of various cellular proteins. By inhibiting PP1 and PP2A, Sal003 enhances the phosphorylation of target proteins, making it valuable for research into cell signaling, particularly in studies of apoptosis, cell cycle regulation, and neuroprotection. Its effects on phosphorylation pathways make Sal003 a useful tool for exploring molecular mechanisms in cancer biology and neurodegenerative diseases, advancing understanding of phosphatase regulation in therapeutic development.

Reference

[1]. Costa-Mattioli M, et al. eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell. 2007 Apr 6;129(1):195-206.
[2]. Yahiro K, et al. Regulation of subtilase cytotoxin-induced cell death by an RNA-dependent protein kinase-like endoplasmic reticulum kinase-dependent proteasome pathway in HeLa cells. Infect Immun. 2012 May;80(5):1803-14.
[3]. Jian M, et al. eIF2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. J Neurosci. 2014 Jul 23;34(30):10010-21.