For research use only. Not for therapeutic Use.
Salermide（Cat No.:I009277）is a small molecule compound known for its potential anti-cancer properties, primarily through the inhibition of the protein deacetylase SIRT1 (Sirtuin 1). By targeting SIRT1, salermide can affect various cellular processes, including apoptosis, cell cycle regulation, and metabolic pathways, potentially leading to increased sensitivity of cancer cells to chemotherapy. It has shown promise in preclinical studies against several cancer types, including leukemia and solid tumors. Research is ongoing to better understand its mechanisms, therapeutic potential, and safety profile in clinical settings, aiming to improve cancer treatment strategies.
| Catalog Number | I009277 |
| CAS Number | 1105698-15-4 |
| Synonyms | Salermide;N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide |
| Molecular Formula | C₂₆H₂₂N₂O₂ |
| Purity | ≥95% |
| Target | Sirtuin |
| Solubility | Soluble in DMSO |
| Storage | Store at +4C |
| IUPAC Name | N-[3-[(2-hydroxynaphthalen-1-yl)methylideneamino]phenyl]-2-phenylpropanamide |
| InChI | InChI=1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30) |
| InChIKey | HQSSEGBEYORUBY-UHFFFAOYSA-N |
| SMILES | CC(C1=CC=CC=C1)C(=O)NC2=CC(=CC=C2)N=CC3=C(C=CC4=CC=CC=C43)O |
| Reference | </br>1:HDAC inhibitors, MS-275 and salermide, potentiates the anticancer effect of EF24 in human pancreatic cancer cells. Yar Saglam AS, Yilmaz A, Onen HI, Alp E, Kayhan H, Ekmekci A.EXCLI J. 2016 Apr 4;15:246-55. doi: 10.17179/excli2016-186. eCollection 2016. PMID: 27330528 Free PMC Article</br>2:Combination of Salermide and Cholera Toxin B Induce Apoptosis in MCF-7 but Not in MRC-5 Cell Lines. Salahshoor MR, Dastjerdi MN, Jalili C, Mardani M, Khazaei M, Darehdor AS, Valiani A, Roshankhah S.Int J Prev Med. 2013 Dec;4(12):1402-13. PMID: 24498496 Free PMC Article</br>3:Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. Rotili D, Tarantino D, Nebbioso A, Paolini C, Huidobro C, Lara E, Mellini P, Lenoci A, Pezzi R, Botta G, Lahtela-Kakkonen M, Poso A, Steinkühler C, Gallinari P, De Maria R, Fraga M, Esteller M, Altucci L, Mai A.J Med Chem. 2012 Dec 27;55(24):10937-47. doi: 10.1021/jm3011614. Epub 2012 Dec 12. PMID: 23189967 </br>4:Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells. Liu G, Su L, Hao X, Zhong N, Zhong D, Singhal S, Liu X.J Cell Mol Med. 2012 Jul;16(7):1618-28. doi: 10.1111/j.1582-4934.2011.01401.x. PMID: 21801305 Free PMC Article</br>5:Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, Villar-Garea A, Imhof A, Mato JM, Esteller M, Fraga MF.Oncogene. 2009 Feb 12;28(6):781-91. doi: 10.1038/onc.2008.436. Epub 2008 Dec 8. Erratum in: Oncogene. 2009 Feb 26;28(8):1168. Inhof, A [corrected to Imhof, A]. PMID: 19060927 |
