For research use only. Not for therapeutic Use.
Salinomycin（Cat No.:I003938）is a polyether ionophore antibiotic initially used in veterinary medicine to control coccidial infections in poultry. It disrupts ion transport across cell membranes, targeting protozoa and certain Gram-positive bacteria. Recently, salinomycin gained attention in cancer research for its potential to selectively target and eliminate cancer stem cells, showing promising results in experimental therapies for drug-resistant tumors. Its unique mechanism, involving potassium ion flux, makes it effective against various cancer cell types, adding to its versatility as a research tool for oncology and microbial inhibition.
| Catalog Number | I003938 |
| CAS Number | 53003-10-4 |
| Synonyms | Procoxacin |
| Molecular Formula | C42H70O11 |
| Purity | ≥95% |
| Target | Wnt/β-catenin |
| Solubility | DMSO 23 mg/ml |
| Storage | 3 years -20C powder |
| IUPAC Name | (2R)-2-[(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid |
| InChI | InChI=1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1 |
| InChIKey | KQXDHUJYNAXLNZ-XQSDOZFQSA-N |
| SMILES | CC[C@H]([C@H]1CC[C@@H]([C@@H](O1)[C@@H](C)[C@@H]([C@H](C)C(=O)[C@H](CC)[C@@H]2[C@H](C[C@H]([C@]3(O2)C=C[C@H]([C@@]4(O3)CC[C@@](O4)(C)[C@H]5CC[C@@]([C@@H](O5)C)(CC)O)O)C)C)O)C)C(=O)O |
| Reference | </br>1:Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells. Kim KY, Park KI, Kim SH, Yu SN, Park SG, Kim YW, Seo YK, Ma JY, Ahn SC.Int J Mol Sci. 2017 May 18;18(5). pii: E1088. doi: 10.3390/ijms18051088. PMID: 28524116 </br>2:Salinomycin induces endoplasmic reticulum stress‑mediated autophagy and apoptosis through generation of reactive oxygen species in human glioma U87MG cells. Yu SN, Kim SH, Kim KY, Ji JH, Seo YK, Yu HS, Ahn SC.Oncol Rep. 2017 May 2. doi: 10.3892/or.2017.5615. [Epub ahead of print] PMID: 28498472 </br>3:Salinomycin acts through reducing AKT-dependent thymidylate synthase expression to enhance erlotinib-induced cytotoxicity in human lung cancer cells. Tung CL, Chen JC, Wu CH, Peng YS, Chen WC, Zheng HY, Jian YJ, Wei CL, Cheng YT, Lin YW.Exp Cell Res. 2017 Apr 25. pii: S0014-4827(17)30253-7. doi: 10.1016/j.yexcr.2017.04.026. [Epub ahead of print] PMID: 28454878 </br>4:Salinomycin overcomes radioresistance in nasopharyngeal carcinoma cells by inhibiting Nrf2 level and promoting ROS generation. Zhang G, Wang W, Yao C, Ren J, Zhang S, Han M.Biomed Pharmacother. 2017 Apr 25;91:147-154. doi: 10.1016/j.biopha.2017.04.095. [Epub ahead of print] PMID: 28453992 </br>5:Therapeutic PEG-ceramide nanomicelles synergize with salinomycin to target both liver cancer cells and cancer stem cells. Wang M, Xie F, Wen X, Chen H, Zhang H, Liu J, Zhang H, Zou H, Yu Y, Chen Y, Sun Z, Wang X, Zhang G, Yin C, Sun D, Gao J, Jiang B, Zhong Y, Lu Y.Nanomedicine (Lond). 2017 May;12(9):1025-1042. doi: 10.2217/nnm-2016-0408. Epub 2017 Apr 25. PMID: 28440698 </br>6:Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells. Dunlop EA, Johnson CE, Wiltshire M, Errington RJ, Tee AR.Oncotarget. 2017 Mar 15. doi: 10.18632/oncotarget.16232. [Epub ahead of print] PMID: 28415776 Free Article</br>7:Mechanism of salinomycin overproduction in Streptomyces albus as revealed by comparative functional genomics. Zhang X, Lu C, Bai L.Appl Microbiol Biotechnol. 2017 Apr 11. doi: 10.1007/s00253-017-8278-5. [Epub ahead of print] PMID: 28401259 </br>8:Salinomycin attenuates liver cancer stem cell motility by enhancing cell stiffness and increasing F-actin formation via the FAK-ERK1/2 signalling pathway. Sun J, Luo Q, Liu L, Yang X, Zhu S, Song G.Toxicology. 2017 Jun 1;384:1-10. doi: 10.1016/j.tox.2017.04.006. Epub 2017 Apr 8. PMID: 28395993 </br>9:Salinomycin Induces Reactive Oxygen Species and Apoptosis in Aggressive Breast Cancer Cells as Mediated with Regulation of Autophagy. Kim KY, Park KI, Kim SH, Yu SN, Lee D, Kim YW, Noh KT, Ma JY, Seo YK, Ahn SC.Anticancer Res. 2017 Apr;37(4):1747-1758. PMID: 28373437 </br>10:Salinomycin exhibits anti-angiogenic activity against human glioma in vitro and in vivo by suppressing the VEGF-VEGFR2-AKT/FAK signaling axis. Bi YL, Mi PY, Zhao SJ, Pan HM, Li HJ, Liu F, Shao LR, Zhang HF, Zhang P, Jiang SL.Int J Mol Med. 2017 May;39(5):1255-1261. doi: 10.3892/ijmm.2017.2940. Epub 2017 Mar 29. PMID: 28358414 Free PMC Article |
