Salinosporamide C

• CAT Number: I035952
• CAS Number: 863126-96-9
• Molecular Formula: C14H18ClNO3
• Molecular Weight: 283.75
• Purity: 98%
• Synonyms: Salinosporamide C
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (4aR,8aS,9S,9aR)-2-(2-chloroethyl)-9-hydroxy-1-methyl-4a,7,8,8a,9,9a-hexahydro-3H-pyrrolo[1,2-a]indole-3,6(5H)-dione
• InChI: InChI=1S/C14H18ClNO3/c1-7-9(4-5-15)14(19)16-11-6-8(17)2-3-10(11)13(18)12(7)16/h10-13,18H,2-6H2,1H3/t10-,11+,12+,13-/m0/s1
• InChIKey: LSKWKCUUZBBJFE-LOWDOPEQSA-N
• SMILES: O=C1C(CCCl)=C(C)[C@@]([C@@H](O)[C@@]2([H])CC3)([H])N1[C@]2([H])CC3=O

Salinosporamide C is a decarboxylated pyrrole analogue isolated from the marine Actinomycete Salinispora tropica.

Reference

1: Dineshkumar K, Vasudevan A, Hopper W. Ligand Based-Pharmacophore Modeling and Extended Bi oactivity Prediction for Salinosporamide A, B and C from Marine Actino mycetes Salinispora tropica. Comb Chem High Throughput Screen. 2017;20(1):3-19. doi: 10.2174/1386207319666161215154128. PubMed PMID: 28000560.
2: Williams PG, Buchanan GO, Feling RH, Kauffman CA, Jensen PR, Fenical W. New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica. J Org Chem. 2005 Aug 5;70(16):6196-203. PubMed PMID: 16050677.
3: Tsueng G, Sing Lam K. Effect of cobalt and vitamin B12 on the production of salinosporamides by Salinispora tropica. J Antibiot (Tokyo). 2009 Apr;62(4):213-6. doi: 10.1038/ja.2009.7. Epub 2009 Feb 6. PubMed PMID: 19198638.