For research use only. Not for therapeutic Use.
Salinosporamide C（Cat No.:I035952）is a natural product isolated from the marine bacterium Salinispora tropica. It belongs to a class of compounds known as proteasome inhibitors, which target the 26S proteasome, a key enzyme complex responsible for degrading unwanted proteins in cells. By inhibiting the proteasome, salinosporamide C induces cellular stress and apoptosis, making it a promising candidate for cancer therapy. Its potent anticancer activity has been demonstrated in preclinical studies, particularly against various solid tumors, and it is being investigated for potential use in treating drug-resistant cancers.
| Catalog Number | I035952 |
| CAS Number | 863126-96-9 |
| Synonyms | Salinosporamide C; |
| Molecular Formula | C14H18ClNO3 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (3aR,4S,4aS,8aR)-2-(2-chloroethyl)-4-hydroxy-3-methyl-4,4a,5,6,8,8a-hexahydro-3aH-pyrrolo[1,2-a]indole-1,7-dione |
| InChI | InChI=1S/C14H18ClNO3/c1-7-9(4-5-15)14(19)16-11-6-8(17)2-3-10(11)13(18)12(7)16/h10-13,18H,2-6H2,1H3/t10-,11+,12+,13-/m0/s1 |
| InChIKey | LSKWKCUUZBBJFE-LOWDOPEQSA-N |
| SMILES | CC1=C(C(=O)N2[C@H]1[C@H]([C@@H]3[C@H]2CC(=O)CC3)O)CCCl |
| Reference | 1: Dineshkumar K, Vasudevan A, Hopper W. Ligand Based-Pharmacophore Modeling and Extended Bi oactivity Prediction for Salinosporamide A, B and C from Marine Actino mycetes Salinispora tropica. Comb Chem High Throughput Screen. 2017;20(1):3-19. doi: 10.2174/1386207319666161215154128. PubMed PMID: 28000560. |
