Salviolone

• CAT Number: M024482
• CAS Number: 119400-86-1
• Molecular Formula: C18H20O2
• Molecular Weight: 268.35
• Purity: ≥95%
• Synonyms: 9-hydroxy-4,4,8-trimethyl-2,3-dihydro-1H-cyclohepta[a]naphthalen-10-one
• InChI: InChI=1S/C18H20O2/c1-11-9-12-6-7-15-13(5-4-8-18(15,2)3)14(12)10-16(19)17(11)20/h6-7,9-10H,4-5,8H2,1-3H3,(H,19,20)
• InChIKey: QATRODNHXVHGNU-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)C=C2C3=C(C=CC2=C1)C(CCC3)(C)C)O

Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells[1].
Salviolone (5-60 μM; 72 hours) reduces cell viability in the A375 and MeWo melanoma cell lines with EC50 values of 17 µM and 22 µM, respectively. Salviolone does not affect the growth of normal melanocytes[1].
Salviolone (20 μM; 48-72 hours) strongly reduces pRb, pCdk2, and cyclin A2, Tyr705-STAT3 phosphorylation expression levels in A375 cells. Salviolone also strongly increases the P21 and P53 protein expression level. Salviolone induces sustained activation of the phosphorylation of ERK1/2 and Akt[1].
Salviolone (10-20 μM) inhibits MMP2 gelatinase activity in the A375 melanoma cell line[1].

Reference

[1]. Valentina Zanrè, et al. Salviolone from Salvia miltiorrhiza Roots Impairs Cell Cycle Progression, Colony Formation, and Metalloproteinase-2 Activity in A375 Melanoma Cells: Involvement of P21(Cip1/Waf1) Expression and STAT3 Phosphorylation. Int J Mol Sci. 2022 Jan 20;23(3):1121.
 [Content Brief]