Samatasvir

• CAT Number: I035963
• CAS Number: 1312547-19-5
• Molecular Formula: C47H48N8O6S2
• Molecular Weight: 885.07
• Purity: 98%
• Synonyms: Samatasvir; IDX 18719; IDX-18719; IDX18719; IDX 719; IDX-719; IDX719
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: 4°C, protect from light
• IUPAC Name: methyl ((R)-2-((S)-2-(5-(4-(6-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-benzo[d]imidazol-6-yl)thieno[3,2-b]thiophen-3-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)carbamate
• InChI: InChI=1S/C47H48N8O6S2/c1-26(2)38(52-46(58)60-3)44(56)55-21-9-13-37(55)43-49-33-19-18-30(22-34(33)50-43)32-25-63-40-31(24-62-41(32)40)27-14-16-28(17-15-27)35-23-48-42(51-35)36-12-8-20-54(36)45(57)39(53-47(59)61-4)29-10-6-5-7-11-29/h5-7,10-11,14-19,22-26,36-39H,8-9,12-13,20-21H2,1-4H3,(H,48,51)(H,49,50)(H,52,58)(H,53,59)/t36-,37-,38-,39+/m0/s1
• InChIKey: ATOLIHZIXHZSBA-BTSKBWHGSA-N
• SMILES: O=C(OC)N[C@H](C1=CC=CC=C1)C(N2[C@H](C3=NC=C(C4=CC=C(C5=CSC6=C5SC=C6C7=CC=C8N=C([C@H]9N(C([C@@H](NC(OC)=O)C(C)C)=O)CCC9)NC8=C7)C=C4)N3)CCC2)=O

Samatasvir（Cat No.:I035963）, also known as IDX719, is a potent, pan-genotypic inhibitor of the hepatitis C virus (HCV) NS5A protein, which is essential for viral replication and assembly. Samatasvir is administered orally and has demonstrated high efficacy in clinical trials for the treatment of chronic HCV infection, both as monotherapy and in combination with other antiviral agents. It has a favorable safety profile with minimal side effects and can be used to treat a broad range of HCV genotypes.

Reference

1: Vince B, Hill JM, Lawitz EJ, O’Riordan W, Webster LR, Gruener DM, Mofsen RS, Murillo A, Donovan E, Chen J, McCarville JF, Sullivan-Bólyai JZ, Mayers D, Zhou XJ. A randomized, double-blind, multiple-dose study of the pan-genotypic NS5A inhibitor samatasvir in patients infected with hepatitis C virus genotype 1, 2, 3 or 4. J Hepatol. 2014 May;60(5):920-7. doi: 10.1016/j.jhep.2014.01.003. Epub 2014 Jan 14. PubMed PMID: 24434503.
2: Bilello JP, Lallos LB, McCarville JF, La Colla M, Serra I, Chapron C, Gillum JM, Pierra C, Standring DN, Seifer M. In vitro activity and resistance profile of samatasvir, a novel NS5A replication inhibitor of hepatitis C virus. Antimicrob Agents Chemother. 2014 Aug;58(8):4431-42. doi: 10.1128/AAC.02777-13. Epub 2014 May 27. PubMed PMID: 24867983; PubMed Central PMCID: PMC4136001.