Santacruzamate A

• CAT Number: I013795
• CAS Number: 1477949-42-0
• Molecular Formula: C15H22N2O3
• Molecular Weight: 278.35
• Purity: ≥95%
• Synonyms: ethyl N-[4-oxo-4-(2-phenylethylamino)butyl]carbamate
• InChI: InChI=1S/C15H22N2O3/c1-2-20-15(19)17-11-6-9-14(18)16-12-10-13-7-4-3-5-8-13/h3-5,7-8H,2,6,9-12H2,1H3,(H,16,18)(H,17,19)
• InChIKey: HTOYBIILVCHURC-UHFFFAOYSA-N
• SMILES: CCOC(=O)NCCCC(=O)NCCC1=CC=CC=C1

Santacruzamate A (CAY-10683, STA) is a potent and selective HDAC2 inhibitor with an IC50 of 119 pM. STA also exerts neuroprotective property against amyloid-β protein fragment 25–35. STA can be used for cancer and neurological disease research[1][2].
Santacruzamate A (0.016-50 μM, 28 h) attenuates amyloid-β protein fragment 25–35-induced apoptosis and reverses Aβ25–35-induced unfolded protein response and endoplasmic reticulum stress in PC12 and SH-SY5Y. 2 μM STA shows the strongest protective effects[2].
Santacruzamate A (0.016-50 μM, 12 h) up-regulates KDEL receptor (KDELR) expression, reinforces ER luminal retention of chaperones, and enhances the binding of PERK to GRP78, inhibiting the amyloid-β protein fragment 25–35-induced mitochondrial fission and apoptosis pathways in PC12[2].

Reference

[1]. Pavlik CM,et al. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33.
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