For research use only. Not for therapeutic Use.
SAR-020106（Cat No.:I009280）is a potent and selective inhibitor of checkpoint kinase 1 (Chk1), a key enzyme involved in the DNA damage response and cell cycle regulation. By inhibiting Chk1, SAR-020106 impairs the ability of cancer cells to repair damaged DNA, particularly during replication stress, leading to cell cycle arrest and apoptosis. This compound is widely used in cancer research, particularly in combination with DNA-damaging agents like chemotherapy or radiation, to enhance their efficacy. SAR-020106 is valuable for exploring novel therapeutic strategies targeting DNA repair mechanisms in cancer treatment.
| Catalog Number | I009280 |
| CAS Number | 1184843-57-9 |
| Synonyms | SAR020106; SAR020106; SAR 020106; SAR20106; SAR20106; SAR 20106.;(R)-5-((8-chloroisoquinolin-3-yl)amino)-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile |
| Molecular Formula | C19H19ClN6O |
| Purity | ≥95% |
| Target | Checkpoint Kinase (Chk) |
| Solubility | soluble in DMSO, not soluble in water. |
| Storage | Store at +4C |
| IUPAC Name | 5-[(8-chloroisoquinolin-3-yl)amino]-3-[(2R)-1-(dimethylamino)propan-2-yl]oxypyrazine-2-carbonitrile |
| InChI | InChI=1S/C19H19ClN6O/c1-12(11-26(2)3)27-19-16(8-21)22-10-18(25-19)24-17-7-13-5-4-6-15(20)14(13)9-23-17/h4-7,9-10,12H,11H2,1-3H3,(H,23,24,25)/t12-/m1/s1 |
| InChIKey | SRBJWIBAMIKCMV-GFCCVEGCSA-N |
| SMILES | C[C@H](CN(C)C)OC1=NC(=CN=C1C#N)NC2=NC=C3C(=C2)C=CC=C3Cl |
| Reference | </br>1:Targeted radiosensitization by the Chk1 inhibitor SAR-020106. Borst GR, McLaughlin M, Kyula JN, Neijenhuis S, Khan A, Good J, Zaidi S, Powell NG, Meier P, Collins I, Garrett MD, Verheij M, Harrington KJ.Int J Radiat Oncol Biol Phys. 2013 Mar 15;85(4):1110-8. doi: 10.1016/j.ijrobp.2012.08.006. Epub 2012 Sep 14. PMID: 22981708 </br>2:The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106. Walton MI, Eve PD, Hayes A, Valenti M, De Haven Brandon A, Box G, Boxall KJ, Aherne GW, Eccles SA, Raynaud FI, Williams DH, Reader JC, Collins I, Garrett MD.Mol Cancer Ther. 2010 Jan;9(1):89-100. doi: 10.1158/1535-7163.MCT-09-0938. Epub 2010 Jan 6. PMID: 20053762 Free Article |
