SAR247799

• CAT Number: I045562
• CAS Number: 1315311-14-8
• Molecular Formula: C21H16ClN3O5
• Molecular Weight: 425.82
• Purity: ≥95%
• Synonyms: 2-[4-[5-(3-chlorophenoxy)-[1,3]oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy]acetic acid
• InChI: InChI=1S/C21H16ClN3O5/c1-11-6-13(7-12(2)18(11)28-10-17(26)27)19-24-16-9-23-21(25-20(16)30-19)29-15-5-3-4-14(22)8-15/h3-9H,10H2,1-2H3,(H,26,27)
• InChIKey: WRBZNIUFAKIIQG-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC(=C1OCC(=O)O)C)C2=NC3=CN=C(N=C3O2)OC4=CC(=CC=C4)Cl

SAR247799 (Cat No.: I045562) is a selective, long-acting sphingosine-1-phosphate receptor 1 (S1P1) agonist developed by Sanofi for cardiovascular and inflammatory disease research. Unlike conventional S1P1 modulators, SAR247799 activates the receptor without causing significant receptor desensitization or lymphopenia, offering improved safety. It enhances endothelial function, vascular protection, and anti-inflammatory effects, making it a promising candidate for treating atherosclerosis, heart failure, and vascular complications in diabetes. In research, SAR247799 serves as a valuable tool for studying S1P signaling, endothelial biology, and therapeutic development.

Reference

[1]. Poirier B, et al. A G protein-biased S1P1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers. Sci Signal. 2020 Jun 2;13(634):eaax8050.
[Content Brief]

[2]. Evaristi MF, et al. A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome. PLoS One. 2022 Jan 14;17(1):e0257929.
[Content Brief]

[3]. Bergougnan L, et al. Endothelial-protective effects of a G-protein-biased sphingosine-1 phosphate receptor-1 agonist, SAR247799, in type-2 diabetes rats and a randomized placebo-controlled patient trial. Br J Clin Pharmacol. 2021 May;87(5):2303-2320.
[Content Brief]

[4]. Bergougnan L, et al. First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G-protein-biased sphingosine-1 phosphate receptor-1 agonist for endothelial protection
[Content Brief]