SAR407899 hydrochloride

• CAT Number: I005490
• CAS Number: 923262-96-8
• Molecular Formula: C14H17ClN2O2
• Molecular Weight: 280.75
• Purity: ≥95%
• Synonyms: 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride
• Target: TGF-beta/Smad
• Solubility: DMSO: ≥ 2.8 mg/mL, DMSO: ＜ 8.2 mg/mL
• Storage: Store at -20°C
• IC50: 36 nM/41 nM(Ki, human/Rat ROCK)
• IUPAC Name: 6-piperidin-4-yloxy-2H-isoquinolin-1-one;hydrochloride
• InChI: InChI=1S/C14H16N2O2.ClH/c17-14-13-2-1-12(9-10(13)3-8-16-14)18-11-4-6-15-7-5-11;/h1-3,8-9,11,15H,4-7H2,(H,16,17);1H
• InChIKey: KMNVOGVCCZNVNU-UHFFFAOYSA-N
• SMILES: C1CNCCC1OC2=CC3=C(C=C2)C(=O)NC=C3.Cl

SAR407899 Hydrochloride(CAT: I005490) is a highly selective rho kinase (ROCK) inhibitor widely used in cardiovascular and neurological research. By targeting ROCK1 and ROCK2, it disrupts critical signaling pathways involved in vascular contraction, endothelial dysfunction, and neuronal apoptosis. This compound has been extensively studied for its potential in treating hypertension, pulmonary arterial hypertension (PAH), and stroke. SAR407899 Hydrochloride exhibits excellent pharmacological properties, including high purity and stability, ensuring reliable experimental results. Its ability to modulate the cytoskeletal dynamics and cellular migration makes it an essential tool for investigating ROCK-related mechanisms in cardiovascular, neurodegenerative, and fibrotic diseases.