SAR502250

• CAT Number: I036003
• CAS Number: 503860-57-9
• Molecular Formula: C19H18FN5O2
• Molecular Weight: 367.38
• Purity: 98%
• Synonyms: SAR502250; SAR 502250; SAR-502250
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-[(2S)-2-(4-fluorophenyl)morpholin-4-yl]-3-methyl-6-pyrimidin-4-ylpyrimidin-4-one
• InChI: InChI=1S/C19H18FN5O2/c1-24-18(26)10-16(15-6-7-21-12-22-15)23-19(24)25-8-9-27-17(11-25)13-2-4-14(20)5-3-13/h2-7,10,12,17H,8-9,11H2,1H3/t17-/m1/s1
• InChIKey: NKUNFNVAHJNALA-QGZVFWFLSA-N
• SMILES: CN1C(=O)C=C(N=C1N2CCO[C@H](C2)C3=CC=C(C=C3)F)C4=NC=NC=C4

SAR502250（Cat No.:I036003）is an investigational small molecule that functions as a potent and selective inhibitor of the enzyme aldehyde dehydrogenase 2 (ALDH2). ALDH2 plays a key role in detoxifying aldehydes, particularly acetaldehyde, a byproduct of alcohol metabolism. SAR502250 is being studied for its potential therapeutic applications in alcohol-related disorders, such as alcohol use disorder (AUD) and alcohol-induced liver injury, as well as in certain cardiovascular conditions. By inhibiting ALDH2, SAR502250 may reduce the harmful effects of acetaldehyde accumulation, potentially improving treatment outcomes for these conditions. Research is ongoing to assess its clinical safety and efficacy.